“Take a deep breath” is what is said to someone who is losing it or anxious. Does it really help? Empirically most of us would agree it does. But is there scientific evidence for the same and do we understand how exactly the human body reacts to controlled breathing and stress relief? Apparently, now we do, show recent studies.

“The Bhagavad Gita, a Hindu scripture from 1st or 2nd century BC talks about “pranayama”—a yoga practice of controlling the breath—and yoga texts from a few centuries later describe its benefits for steadying the mind. For modern breathwork-enthusiasts who say that guided breathing helps them feel better, it undoubtedly does. But to test whether such exercises can reduce stress in the as-yet-unconverted, you need randomised-controlled trials (RCTs).

A meta-analysis published in Scientific Reports in 2023 compiled the results of 12 RCTs, including some 785 participants, to examine the effect of slow-breathing on stress. The studies used a mixture of in-person coaching, online classes or self-guided breathing. Participants who took part in the breathwork sessions reported greater stress-reduction than those in the control group.

…In 2023 researchers at Stanford University published a study in Cell Reports Medicine. Participants performed either mindfulness, “cyclic sighing” (two short inhales, one long exhale), “box-breathing” (inhale, pause, exhale, pause), or “cyclic hyperventilation” (30 short inhales and exhales, followed by a 15 second pause), for five minutes a day, for a month. Everyone got an initial mood boost at the start, but only those who were doing breathwork reported that their mood continued to improve as the study progressed. The best results were in the cyclic-sighing group.

How might breathing control mood? One idea is that it forces attention away from negative or stressful thoughts. Researchers have also found that voluntarily slowing breathing can increase heart-rate variability—the fluctuations in the timing between heart beats. This is often low in people with psychiatric disorders like depression, bipolar and ADHD; increasing it, the theory goes, should therefore be a good thing. There is also evidence that slow breathing and stress regulation might share brain circuits, at least in rodents. A study published in Nature Neuroscience in November 2024, found that stimulating a pathway that causes slow breathing in mice also suppressed their anxiety behaviours.”

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